Absolute flow and resistance have a lower variability in repeated testing as compared to CFR and IMR: an EDIT-CMD substudy

Abstract Background Invasive coronary function testing (CFT), including both acetylcholine (ACH) spasm provocation and assessment of flow resistance, is recommended to assess vasomotor dysfunction (CVDys) in patients with angina non-obstructive artery disease (ANOCA). Objectives To determine repeat reliability invasive measurements CVDys. Methods In the EDIT-CMD trial, 73 underwent baseline follow-up CFT after six weeks. Repeat for CVDys assessment, reserve (CFR), index microvascular resistance (IMR), absolute (Q) (R) was assessed by 1.) comparing continuous values between measurement, difference correlation two 2.) classification agreement (CCA) presence CMD according cut-offs, which also ACH test 3.) Bland-Altman plots. Fisher-Z scores were used compare correlations. Results Mean CFR 3.1±1.5 at 4.1±1.5 (P=0.03), no significant (ρ=0.285, P=0.10). IMR 27±12 27±19 (P=0.94), a trend (ρ=0.312, P=0.07). The CCA 74% 57% IMR. Q 183±72 192±78 (P=0.49), (ρ=0.579, P<0.001). R 527±233 506±228 (P=0.67), (ρ=0.51, p=0.03). 6 weeks 72% this 82%. coefficient (ρ) significantly better than ρ (P=0.006). did not differ. For we found 79% measurements. Conclusion This first study re-test CFT. Measurements show higher their surrogates assessing function. demonstrated good reliability. Funding Acknowledgement Type funding sources: Private company. Main source(s): Abbott